Depression and Anxiety

In psychological tasks, such as self-evaluation, the frontal lobe provides regulatory control over emotional responses in limbic regions. Research in the EGI's Brain Electrophysiology Laboratory examines the dynamic changes in frontolimbic activity that discriminates clinically depressed and anxious from normal persons. By understanding these processes, we may be able to guide both biological and cognitive treatments for depression and anxiety.




Chung, G., Tucker, D. M., West, P., Potts, G. F., Liotti, M., Luu, P. et al. (1996). Emotional expectancy: brain electrical activity associated with an emotional bias in interpreting life events. Psychophysiology, 33(3), 218-233.

Luu, P., Collins, P., & Tucker, D. M. (2000). Mood, personality, and self-monitoring: negative affect and emotionality in relation to frontal lobe mechanisms of error monitoring. J Exp Psychol Gen, 129(1), 43-60.

Luu, P. & Tucker, D. M. (2003). Self-Regulation by the Medial Frontal Cortex: Limbic Representation of Motive Set-Points. In M. Beauregard (Ed.), Consciousness, emotional self-regulation and the brain. Amsterdam: John Benjamins.

Tucker, D. M. (2001). Motivated Anatomy: A core-and-shell model of corticolimbic architecture. In G. Gainotti (Ed.), Handbook of Neuropsychology, 2nd Edition, Volume 5: Emotional behavior and its disorders. (pp. 125-160). Amsterdam: Elsevier.

Tucker, D. M., Derryberry, D., & Luu, P. (2000). Anatomy and Physiology of Human Emotion: Vertical Integration of Brainstem, Limbic, and Cortical Systems. In J. Borod (Ed.), Handbook of the Neuropsychology of Emotion. (pp. 56-79). New York: Oxford.

Tucker, D. M., Luu, P., & Derryberry, D. (2005). Love hurts: The evolution of empathic concern through the encephalization of nociceptive capacity. Dev Psychopathol, 17(3), 699-713.

Tucker, D. M., Luu, P., Desmond, R. E., Jr., Hartry-Speiser, A., Davey, C., & Flaisch, T. (2003). Corticolimbic mechanisms in emotional decisions. Emotion, 3(2), 127-149.

Tucker, D. M., Luu, P., Frishkoff, G., Quiring, J., & Poulsen, C. (2003). Frontolimbic response to negative feedback in clinical depression. J Abnorm Psychol, 112(4), 667-678.

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